John J Lemasters Selected Research

Ligation

12/2019	Aldehyde dehydrogenase-2 activation by Alda-1 decreases necrosis and fibrosis after bile duct ligation in mice.
12/2008	NIM811 (N-methyl-4-isoleucine cyclosporine), a mitochondrial permeability transition inhibitor, attenuates cholestatic liver injury but not fibrosis in mice.
11/2003	Polyphenols from Camellia sinenesis attenuate experimental cholestasis-induced liver fibrosis in rats.
11/2003	NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis.
10/2002	Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

John J Lemasters Research Topics

Disease

46	Necrosis 11/2023 - 02/2002
24	Mitochondrial Diseases (Mitochondrial Disease) 04/2023 - 02/2002
19	Ischemia 01/2022 - 10/2002
17	Neoplasms (Cancer) 01/2021 - 02/2006
13	Reperfusion Injury 04/2023 - 05/2002
10	Hypoxia (Hypoxemia) 11/2020 - 02/2006
9	Inflammation (Inflammations) 01/2022 - 10/2003
9	Fibrosis (Cirrhosis) 12/2019 - 11/2003
7	Hemorrhage 09/2014 - 03/2003
6	Hepatocellular Carcinoma (Hepatoma) 11/2020 - 12/2002
6	Fatty Liver 01/2017 - 05/2004
6	Hemorrhagic Shock 09/2014 - 04/2003
5	Liver Cirrhosis (Hepatic Cirrhosis) 01/2016 - 11/2003
4	Hyperbilirubinemia 01/2017 - 02/2011
3	Alcoholic Liver Diseases (Alcoholic Liver Disease) 11/2022 - 09/2018
3	Liver Failure 11/2018 - 11/2004
3	Hepatitis 11/2018 - 02/2002
3	Body Weight (Weight, Body) 01/2018 - 08/2010
3	Myocardial Infarction 03/2014 - 11/2008
3	Liver Diseases (Liver Disease) 08/2013 - 02/2006
3	Cholestasis 12/2008 - 11/2003
2	Acute Liver Failure (Fulminant Hepatic Failure) 01/2022 - 02/2011
2	Ventricular Remodeling 03/2014 - 01/2014
2	Atrophy 01/2014 - 11/2006
2	Multiple Organ Failure (MODS) 01/2012 - 08/2010

Drug/Important Bio-Agent (IBA)

18	Alanine Transaminase (SGPT)IBA 01/2022 - 08/2004
16	Acetaminophen (Paracetamol)FDA LinkGeneric 11/2023 - 11/2004
14	Adenosine Triphosphate (ATP)IBA 01/2021 - 02/2002
9	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 11/2003
8	IronIBA 01/2022 - 11/2008
8	Ethanol (Ethyl Alcohol)IBA 11/2018 - 05/2004
8	TubulinIBA 01/2018 - 12/2010
8	Oxygen (Dioxygen)IBA 02/2011 - 04/2003
7	Minocycline (Cyclops)FDA LinkGeneric 10/2023 - 01/2008
7	Cyclosporine (Ciclosporin)FDA LinkGeneric 03/2014 - 10/2002
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 10/2002
5	Glutathione (Reduced Glutathione)IBA 01/2018 - 11/2004
5	Caspase 3 (Caspase-3)IBA 09/2014 - 07/2003
5	BilirubinIBA 02/2013 - 05/2008
5	CytokinesIBA 01/2012 - 10/2003
4	Voltage-Dependent Anion ChannelsIBA 11/2022 - 09/2012
4	erastinIBA 01/2018 - 04/2013
4	BuffersIBA 04/2012 - 06/2004
4	(melle-4)cyclosporinIBA 01/2012 - 01/2008
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2012 - 10/2002
4	PolyphenolsIBA 08/2010 - 11/2003
4	Free RadicalsIBA 05/2008 - 07/2003
3	JNK Mitogen-Activated Protein KinasesIBA 04/2023 - 01/2012
3	AcetaldehydeIBA 11/2022 - 02/2006
3	Mitochondrial DNA (mtDNA)IBA 11/2022 - 02/2002
3	Peroxynitrous Acid (Peroxynitrite)IBA 01/2022 - 07/2010
3	Deferoxamine (Desferal)FDA LinkGeneric 01/2022 - 10/2013
3	4-hydroxy-2-nonenal (4-hydroxynonenal)IBA 01/2022 - 09/2006
3	Superoxides (Superoxide)IBA 01/2022 - 04/2003
3	Adenosine Diphosphate (ADP)IBA 01/2021 - 01/2016
3	AntioxidantsIBA 01/2018 - 08/2004
3	Acetylcysteine (Siran)FDA LinkGeneric 01/2018 - 11/2006
3	Adenine NucleotidesIBA 10/2017 - 04/2013
3	Protein Isoforms (Isoforms)IBA 01/2016 - 07/2003
3	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 09/2014 - 10/2003
3	DNA (Deoxyribonucleic Acid)IBA 09/2014 - 10/2003
3	Tetracycline (Achromycin)FDA LinkGeneric 09/2014 - 01/2012
3	Photosensitizing Agents (Photosensitizers)IBA 01/2013 - 07/2009
3	HEPESIBA 04/2012 - 06/2004
3	Oxidants (Oxidizing Agents)IBA 08/2011 - 08/2004
3	Phosphotransferases (Kinase)IBA 09/2006 - 06/2004
2	CeramidesIBA 02/2024 - 10/2012
2	Anti-Bacterial Agents (Antibiotics)IBA 10/2023 - 01/2022
2	Histone Deacetylase InhibitorsIBA 04/2023 - 01/2018
2	tetramethylrhodamine (T 489)IBA 11/2022 - 12/2010
2	Propidium (Propidium Iodide)IBA 11/2022 - 11/2013
2	Alanine (L-Alanine)FDA Link 01/2022 - 11/2006
2	TransferasesIBA 01/2022 - 11/2006
2	AldehydesIBA 01/2020 - 12/2019
2	Starch (Cornstarch)IBA 01/2020 - 10/2013
2	mitoquinoneIBA 01/2018 - 01/2016
2	EnzymesIBA 01/2018 - 09/2014
2	AcidsIBA 01/2018 - 04/2007
2	Lactic Acid (Lactate)FDA LinkGeneric 01/2018 - 10/2010
2	Peroxidase (Myeloperoxidase)IBA 01/2015 - 11/2006
2	Doxycycline (Periostat)FDA LinkGeneric 09/2014 - 11/2013
2	Ringer's SolutionIBA 09/2014 - 05/2002
2	Ru 360IBA 11/2013 - 10/2013
2	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/2013 - 07/2009
2	phthalocyanineIBA 03/2012 - 07/2009
2	ChemokinesIBA 01/2012 - 10/2003
2	Mitogen-Activated Protein Kinase 9IBA 01/2012 - 05/2008
2	Messenger RNA (mRNA)IBA 01/2012 - 10/2002
2	SphingosineIBA 01/2012 - 01/2012
2	3-nitrotyrosineIBA 02/2011 - 07/2010
2	NitrogenIBA 08/2010 - 02/2006
2	Reactive Nitrogen SpeciesIBA 08/2010 - 04/2003
2	Superoxide DismutaseIBA 05/2008 - 07/2003
2	antiarrhythmic peptide (AAP)IBA 11/2006 - 08/2004

Therapy/Procedure

10	Transplantation 01/2017 - 03/2002
9	Liver Transplantation 01/2018 - 05/2004
6	Resuscitation 09/2014 - 04/2003
5	Ligation 12/2019 - 10/2002
5	Therapeutics 01/2016 - 02/2006
3	Photochemotherapy (Photodynamic Therapy) 01/2013 - 07/2009